BCL-W Antibodies

Target Information

Using a PCR-based strategy, an additional protein with life-promoting activity, designated Bcl-w, has been identified. The protein is highly conserved between mouse and human and is encoded by a gene located near the TCRalpha gene on chromosome 14. Bcl-w is expressed in myeloid cell lines but not in T and B lymphocytes, and can be found in a wide range of tissues. An alternative splicing event in exon 4 results in two transcripts. The first, Bcl-w, encodes a protein of 193 amino acids, and the second, Bcl-w/rox, encodes a protein 333 amino acids in length. The "rox" portion of Bcl-w/rox shows a striking 66% amino acid sequence identity with the Drosophila rox2 protein; however, the Bcl-w/rox transcript may be expressed at very low levels.

Synonyms

Apoptosis regulator Bcl-W; AW048834; BCL2 like 2; BCL2L2; bcl2-L-2; Bcl2-like 2; BCL2-like 2 protein; Bcl-2-like protein 2; Bcl2-like protein 2; Bclw; BCL-W; BCL-WEL; BCL-WS; c98; Gtrgal2; Gtrosa41; KIAA0271; PPP1R51; protein phosphatase 1, regulatory subunit 51