High quality siRNA reagents for potent gene silencing
siRNA, or small interfering RNA, are double-stranded RNA molecules that play a role in the endogenous RNA interference (RNAi) pathway. RNAi using siRNA is the best way to effectively knock down gene expression to study protein function in a wide range of cell types.
- Choose from guaranteed, pre-designed siRNAs targeting human, mouse, or rat
- Validated siRNAs available against key human and mouse targets
- Specificity-enhanced siRNA reduces the likelihood of off-target effects
Choose from our pre-designed siRNA product lines
| Silencer Select siRNA | Stealth RNAi siRNA | Silencer siRNA | |
| RECOMMENDED Highest knockdown, fewest off-targets | Good knockdown, reduced off-targets | Cost-effective, guaranteed siRNA | |
| Potency (recommended working conc.) | 5 nM | 20 nM | 50 nM |
| Silencing guarantee Learn more | 2 of 2 siRNA | 2 of 3 siRNA | 2 of 3 siRNA |
| Target specificity | Highest | High | Moderate |
| Chemical modifications, length |
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| Gene types targeted |
| Protein-coding genes | Protein-coding genes |
| siRNA libraries |
| N/A | |
| Target species | Human, mouse, rat (Other species: order custom designs) | ||
| Custom siRNA ordering tool | Custom Silencer Select siRNA | Custom Stealth RNAi siRNA | Custom Silencer siRNA |
Libraries
Controls
In vivo RNAi
New to siRNA? Complete the RNAi workflow with optimal siRNA delivery and tools for mRNA knockdown detection!
siRNA videos
Meet the inventor: Susan Magdaleno discusses Silencer Select siRNA technology.
Dr. Gavin Robertson describes how Silencer Select siRNA technology is advancing melanoma research.
