PTPRN2 Proteins

Protein Information

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.

Synonyms

4930425H11Rik; EC 3.1.3.48; IA-2 beta; IA2beta; IA-2beta; IA-2beta60; IA-2beta64; IA-2beta71; IAR; IAR/receptor-like protein-tyrosine phosphatase; ICAAR; Islet cell autoantigen-related protein; KIAA0387; mKIAA0387; phogrin; Phol; protein tyrosine phosphatase receptor pi; protein tyrosine phosphatase receptor-type N polypeptide 2; protein tyrosine phosphatase, receptor type N2; protein tyrosine phosphatase, receptor type, N polypeptide 2; protein tyrosine phosphatase, receptor-type, N polypeptide 2; protein tyrosine phosphatase-NP; PTP IA-2beta; PTP NE-6; PTPNE6; PTP-NP; PTPRN2; PTPRP; receptor-type tyrosine-protein phosphatase N2; R-PTP-N2; tyrosine phosphatase IA-2 beta