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Invitrogen
Human PTPRN2 (aa 187-301) Control Fragment Recombinant Protein
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Product Details
RP-88693
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Amino acid sequence
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Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (54%), Rat (54%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-55367. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: EC 3.1.3.48; IAR; IAR/receptor-like protein-tyrosine phosphatase; Islet cell autoantigen-related protein; Phogrin; protein tyrosine phosphatase receptor pi; protein tyrosine phosphatase, receptor type, N polypeptide 2; R-PTP-N2; Receptor-type tyrosine-protein phosphatase N2; tyrosine phosphatase IA-2 beta
Gene Aliases: IA-2beta; IAR; ICAAR; KIAA0387; PTPRN2; PTPRP; R-PTP-N2
UniProt ID: (Human) Q92932
Entrez Gene ID: (Human) 5799
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