PRPS2 Proteins

Protein Information

The Phosphoribosyl Pyrophosphate Synthetase 2 (PRPS2) gene plays a critical role in cellular metabolism by encoding an enzyme that conducts a key reaction linking central carbon metabolism and nucleotide production, essential for various biological functions. Structurally, PRPS2 shares a high sequence identity with PRPS1, making it less sensitive to allosteric inhibition and particularly significant in certain oncology contexts due to its upregulation at the translational level in some cancers. The enzyme encoded by PRPS2 is pivotal in coupling protein and nucleotide biosynthesis, aided by a unique cis-regulatory element in its 5' UTR, which is influenced by oncogenic pathways. This gene manifests a tissue-specific expression profile, predominantly in proliferative tissues such as the thymus, lung, and small intestine, highlighting its significance in cell growth and proliferation. The evolutionary origins of PRPS2, along with its functional diversification into multiple PRPS genes in eukaryotes, underscore its indispensable role in cellular physiology and pathology.

Synonyms

2610101M19Rik; AA589463; AI464149; Phophoribosylpyrophosphate synthetase, subunit II; phosphoribosyl pyrophosphate synthase II; phosphoribosyl pyrophosphate synthetase 2; phosphoribosyl pyrophosphate synthetase II; PPRibP; PPRibP synthetase; PRPS2; Prps-2; PRSII; PRS-II; ribose-phosphate diphosphokinase 2; ribose-phosphate pyrophosphokinase 2; testicular secretory protein Li 41