DDHD2 Proteins

Protein Information

DDHD2, also known as KIAA0725p, is a member of the intracellular phospholipase A1 (PLA1) protein family which comprises a group of enzymes that hydrolyze the sn-1 ester bond of phospholipids, producing 2-acyl-lysophospholipids and fatty acids. DDHD2 prefers phosphatidic acid as substrate and has a role in efficient membrane trafficking from the Golgi apparatus to the plasma membrane. The gene of DDHD2 maps to chromosome 8p11.23, and encodes a 711-amino-acid protein with a calculated molecular mass of 81 kDa. It has been reported that DDHD2 immunoblot analysis of various tissue extracts revealed two bands of 90 and 85 kDa.

Synonyms

2010305K11Rik; DDHD domain containing 2; DDHD domain-containing protein 2; Ddhd2; intracellular phospholipase A1gamma; iPLA(1)gamma; Kiaa0725; KIAA0725p; mKIAA0725; PA-PLA1 like; phospholipase DDHD2; SAM, WWE and DDHD domain-containing protein 1; Samwd1; sec23p-interacting protein p125-like phosphatidic acid-preferring phospholipase A1; SPG54