DCAMKL2 Proteins

Protein Information

DCAMKL2 is a serine/threonine kinase involved in signal transduction and cellular communication, and is the human homolog of a rat protein kinase expressed in cerebrocortical lamination that binds microtubules. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified.

Synonyms

6330415M09Rik; AU044875; CaMK-like CREB regulatory kinase 2; CL2; CLICK2; Click-II; CLIK2; DCAMKL2; DCDC3; DCDC3B; Dck2; Dclk2; doublecortin and CaM kinase-like 2; doublecortin domain-containing protein 3B; doublecortin kinase 2; doublecortin like kinase 2; doublecortin-like and CAM kinase-like 2; Doublecortin-like kinase 2; RGD1308384; Serine/threonine-protein kinase DCLK2