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Invitrogen
Human DCAMKL2 Control Fragment Recombinant Protein
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Product Details
RP-91456
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Amino acid sequence
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Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (74%), Rat (74%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-82538. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
DCAMKL2 is a serine/threonine kinase involved in signal transduction and cellular communication, and is the human homolog of a rat protein kinase expressed in cerebrocortical lamination that binds microtubules. The microtubule-polymerizing activity of the encoded protein is independent of its protein kinase activity. Mouse studies show that the DCX gene, another family member, and this gene share function in the establishment of hippocampal organization and that their absence results in a severe epileptic phenotype and lethality, as described in human patients with lissencephaly. Multiple alternatively spliced transcript variants have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Bioinformatics
Protein Aliases: CaMK-like CREB regulatory kinase 2; CL2; doublecortin and CaM kinase-like 2; Doublecortin domain-containing protein 3B; Doublecortin-like and CAM kinase-like 2; Doublecortin-like kinase 2; Serine/threonine-protein kinase DCLK2
Gene Aliases: CL2; CLICK-II; CLICK2; CLIK2; DCAMKL2; DCDC3; DCDC3B; DCK2; DCLK2
UniProt ID: (Human) Q8N568
Entrez Gene ID: (Human) 166614
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