CIS Proteins

Protein Information

CIS contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene.

Synonyms

AI385595; BACTS2; Cis; CIS1; CIS-1; Cish; cytokine inducible SH2 containing protein; cytokine inducible SH2-containing protein; cytokine inducible SH2-containing protein 1; cytokine-inducible inhibitor of signaling type 1B; cytokine-inducible SH2 protein; cytokine-inducible SH2-containing protein; F17; F23; G18; Protein G18; SOCS; suppressor of cytokine signaling