Invitrogen

Human CISD2 Synthetic Peptide

Name: Human CISD2 Synthetic Peptide
Brand: Invitrogen
SKU: PEP-1588

View all (2) CISD2 proteins

Datasheet

Tech Support

Datasheet

Tech Support

Product Details

PEP-1588

Applications

Tested Dilution

Publications

Control (Ctrl)

Assay-dependent

Blocking Assay (BLOCK)

Assay-dependent

Product Specifications

Species Reactivity

Human

Class

Synthetic

Type

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

200 µg/mL

Purification

purified

Storage buffer

PBS, pH 7.2, with 0.1% BSA

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice

Product Specific Information

This peptide corresponds to 15 amino acid peptide near the center of human CISD2.

PEP-1588 can be used as a blocking peptide with polyclonal antibody PA5-34545. For use as a blocking peptide in Western blot, incubate the peptide with equal volume of antibody for 30 min at 37°C.

Target Information

Defects in the CISD2 (CDGSH iron sulfur domain 2) gene are a cause of the neurodegenerative disorder Wolfram syndrome 2. CISD2 is a zinc finger protein that localizes to the endoplasmic reticulum and mitochondria and binds an iron/sulfur cluster. CISD2 interacts with Bcl-2 and can be displaced by the BH3-only protein BIK and contributes to the regulation of BIK-initiated autophagy. CISD2 deficiency in mice causes mitochondrial breakdown accompanied by autophagic cell death as well as the development of premature aging phenotype.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: CDGSH iron-sulfur domain-containing protein 2; Endoplasmic reticulum intermembrane small protein; Miner1; mitoNEET related 1; MitoNEET-related 1 protein; NAF-1; Nutrient-deprivation autophagy factor-1; zinc finger, CDGSH-type domain 2