Invitrogen

Human CCDC105 (aa 231-302) Control Fragment Recombinant Protein

Name: Human CCDC105 (aa 231-302) Control Fragment Recombinant Protein
Brand: Invitrogen
SKU: RP-99135

Datasheet

Tech Support

Datasheet

Tech Support

Product Details

RP-99135

Applications

Tested Dilution

Publications

Control (Ctrl)

Assay-dependent

Blocking Assay (BLOCK)

Assay-dependent

Product Specifications

Species

Human

Expression System

E. coli

Amino acid sequence

RDTLNFCFKERLQAVDLMNQPLDKVLEQARRHSWVNLSRAPTPRTQGQKTPPPDPVGTYNPACALALNEAKR

Tag

His-ABP-tag

Class

Recombinant

Type

Protein

Purity

>80% by SDS-PAGE and Coomassie blue staining

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

≥5.0 mg/mL

Purification

purified

Storage buffer

PBS/1M urea, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Product Specific Information

Highest antigen sequence indentity to the following orthologs: Mouse (79%), Rat (79%).

This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-63588. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.

Target Information

CCDC105 (Coiled-Coil Domain-Containing 105) is a gene that encodes a protein involved in various cellular processes, primarily associated with the structure and function of centrioles and cilia. The CCDC105 protein contains coiled-coil domains that facilitate protein-protein interactions, crucial for the assembly and stabilization of microtubule structures within cells. Studies indicate that CCDC105 plays a key role in ciliogenesis, the process by which cells form cilia, which are essential for cell motility, fluid movement, and signal transduction. Dysregulation or mutations in CCDC105 have been implicated in ciliopathies, a group of disorders arising from defective cilia, leading to symptoms such as respiratory issues, kidney disease, and developmental abnormalities. Research continues to explore the specific molecular mechanisms by which CCDC105 influences ciliary dynamics and its broader implications in human health and disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Coiled-coil domain-containing protein 105; Tektin-like protein 1