TSN Antibodies

Target Information

Translin is a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity. Recombination-associated motifs and translin-binding sites are present at recombination hotspots and may serve as indicators of breakpoints in genes which are fused by translocations. These binding activities may play a crucial role in chromosomal translocation in lymphoid neoplasms. Recent evidence suggests that in combination with a binding partner Trax, Translin binds RNA and mediates trafficking in neurons.

Synonyms

2610034C24Rik; AU040286; BCLF-1; C3PO; Component 3 of promoter of RISC; RCHF1; recombination hotspot associated factor; recombination hotspot-binding protein; REHF-1; TBRBP; TB-RBP; testis brain-RNA binding protein; testis/brain RNA-binding protein; testis/brain-RNA-binding protein; translin; TRSLN; Tsn