XRCC6BP1 Proteins

Protein Information

The protein encoded by this gene is amplified in glioblastomas and interacts with the DNA binding subunit of DNA-dependent protein kinase. This kinase is involved in double-strand break repair (DSB), and higher expression of the encoded protein increases the efficiency of DSB. In addition, comparison to orthologous proteins strongly suggests that this protein is a metalloprotease important in the biosynthesis of mitochondrial ATPase. Several transcript variants encoding different isoforms have been found for this gene.

Synonyms

1110068E08Rik; 2410012H02Rik; ATP23; ATP23 metallopeptidase and ATP synthase assembly factor homolog; Ku70 binding protein 3; Ku70-binding protein 3; KUB3; Mitochondrial inner membrane protease ATP23 homolog; XRCC6 binding protein 1; XRCC6-binding protein 1; Xrcc6bp1