XRCC3 Proteins

Protein Information

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified.

Synonyms

4432412E01Rik; AI182522; AW537713; CMM6; DNA repair protein XRCC3; DNA repair protein XRCC3-like; LOC102551085; RAD51 like; X-ray repair complementing defective repair in Chinese hamster cells 3; X-ray repair cross complementing 3; X-ray repair cross-complementing protein 3; XRCC 3; XRCC3