TIS11D Proteins

Protein Information

TIS11D, also known as ZFP36LA (zinc finger protein 36, C3H type-like 2), BRF2 (butyrate response factor 2), ERF2 or RNF162C, is a 494 amino acid protein that localizes to the nucleus and contains two CSH1-type zinc fingers. Belonging to the TIS11 family of early response proteins, TIS11D is thought to function as a nuclear transcription factor that binds to 5'UUAUUUAUUU-3' core RNA sequences and may regulate growth factor-induced cellular responses. The gene encoding TIS11D maps to human chromosome 2, which houses over 1, 400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes.

Synonyms

BRF2; Butyrate response factor 2; EGF-response factor 2; ERF2; ERF-2; mRNA decay activator protein ZFP36L2; Protein TIS11D; RNF162C; TIS11D; TISD; TPA-induced sequence 11d; ZFP36 ring finger protein like 2; ZFP36 ring finger protein-like 2; ZFP36L2; ZFP36-like 2; zinc finger protein 36, C3H type-like 1; zinc finger protein 36, C3H type-like 2; zinc finger protein 36, C3H type-like 2-like; zinc finger protein 36, C3H1 type-like 2; zinc finger protein, C3H type, 36-like 2