TGIF Proteins

Protein Information

TGIF is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain.

Synonyms

5'-TG-3'-interacting factor 1; AA959811; AI462167; Homeobox protein TGIF1; HPE4; TALE family homeobox; TALE homeobox TG-interacting factor; Tfig; TG interacting factor 1; TGFB induced factor homeobox 1; TGFB-induced factor homeobox 1; TGIF; Tgif1; transforming growth factor-beta-induced factor