TFEB Proteins

Protein Information

The Transcription factor EB (TFEB) is a member in the basic helix-loop-helix leucine zipper superfamily of transcription factors that is translocated in a subset of renal tumors. Recent studies have shown that lysosomal biogenesis is regulated by TFEB, which is in turn regulated by the mammalian target of rapamycin (mTOR) complex 1. Other evidence suggests that TFEB coordinates the major steps of the autophagic pathway by driving the expression of autophagy and lysosomal genes.

Synonyms

Alpha TCFEB; ALPHATFEB; bHLHe35; Class E basic helix-loop-helix protein 35; RP4-696P19.3; T-cell transcription factor EB; Tcfeb; Tfeb; transcription factor EB