TC2N Proteins

Protein Information

The TC2N gene encodes the Tandem C2 domains nuclear protein, which is characterized by the presence of two C2 domains, C2A and C2B, at the C-terminus. These domains are structured as an eight-stranded antiparallel beta-sandwich, initially recognized as a Ca2+ binding module. TC2N's role varies significantly across different types of cancer. It has been identified as an oncogene in lung, gastric, and hepatocellular carcinomas, where its overexpression promotes cell proliferation, migration, and metastasis. Conversely, in breast cancer, TC2N functions as a tumor suppressor, inhibiting distant metastasis and stemness via the PI3K-Akt signaling pathway. These dual roles highlight its complex involvement in tumorigenesis, with its impact being highly context-dependent on the cancer type.

Synonyms

C14orf47; C2 calcium-dependent domain containing 1; C2CD1; membrane targeting (tandem) C2 domain containing 1; Membrane targeting tandem C2 domain-containing protein 1; MTAC2D1; Tac2-N; Tandem C2 domains nuclear protein; tandem C2 domains, nuclear; tandem C2 protein in nucleus; TC2N