PUM1 Proteins

Protein Information

PUM1 (pumilio homolog 1) is a sequence-specific RNA-binding protein that acts as a post-transcriptional repressor by binding the 3'-UTR of mRNA targets. It is a member of the PUF family comprised of evolutionarily conserved RNA-binding proteins. PUM1 binds to an RNA consensus sequence, the Pumilio Response Element (PRE), and 5'-UGUANAUA-3' that is related to the Nanos Response Element (NRE). PUM1 mediates post-transcriptonal repression of transcripts via different mechanisms - acts via direct recruitment of the CCR4-POP2-NOT deadenylase leading to translational inhibition and mRNA degradation. Mutations to the gene can result in spinocerebellar ataxia 47.

Synonyms

AA517475; HSPUM; Kiaa0099; mKIAA0099; PUM1; PUMH; PUMH1; pumilio 1; Pumilio homolog 1; pumilio RNA binding family member 1; pumilio RNA-binding family member 1; pumilio-1; PUML1; Pumm