PTRF Proteins

Protein Information

The polymerase I and transcript release factor (PTRF) enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts, regulating rRNA transcription by promoting the dissociation of transcription complexes and the re-initiation of polymerase I on nascent rRNA transcripts. PTRF also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins, translocating from caveolae to the cytoplasm after insulin stimulation. PTRF is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.

Synonyms

2310075E07Rik; AW546441; Caveolae-associated protein 1; CAVIN; CAVIN1; cavin-1; Cav-p60; CGL4; FKSG13; FLJ90031; Polymerase I and transcript release factor; ptrf; ptrf {ECO:0000312; RGD:1307685}; RNA polymerase I and transcript release factor; TTF-I interacting peptide 12