Pleiotrophin Proteins

Protein Information

Pleiotrophin (PTN) is an 18 kDa secreted heparin and chondroitin-binding protein that is a regulatory cytokine critical to the early development of blood vessels and neurons. High PTN serum levels are associated with a variety of solid tumors. It was shown that patients with multiple myeloma (MM) also have elevated serum levels of this protein. The expression of this protein is very limited in normal adult tissues.

Synonyms

HARP; HBBM; HBBN; HB-GAM; HBGF8; HBGF-8; Hbnf; HBNF1; HBNF-1; heparin affin regulatory peptide; heparin affin regulatory protein; heparin binding factor; heparin-binding brain mitogen; Heparin-binding growth factor 8; heparin-binding growth-associated molecule; heparin-binding neurite outgrowth promoting factor; Heparin-binding neurite outgrowth-promoting factor; Heparin-binding neurite outgrowth-promoting factor 1; heparin-binding neurite promoting factor; heparin-binding neurotorphic factor; heparin-binding neutrophic factor; NEGF1; OSF; Osf1; OSF-1; osteoblastic cell factor; osteoblast-specific factor 1; pleiotrophin; pleiotrophin (heparin binding growth factor 8, neurite growth-promoting factor 1); Pleiotrophin (Heparine binding factor, Hbnf, in the mouse); Ptn