PACRG Proteins

Protein Information

PACRG is a protein that is conserved across metazoans. In vertebrates, this gene is linked in a head-to-head arrangement with the adjacent parkin gene, which is associated with autosomal recessive juvenile Parkinson's disease. These genes are co-regulated in various tissues and they share a bi-directional promoter. Both genes are associated with susceptibility to leprosy. The parkin co-regulated gene protein forms a large molecular complex with chaperones, including heat shock proteins 70 and 90, and chaperonin components. This protein is also a component of Lewy bodies in Parkinson's disease patients, and it suppresses unfolded Pael receptor-induced neuronal cell death.

Synonyms

1700008H23Rik; FLJ32724; GLUP; HAK005771; Hypertension-related protein 1-like protein; Molecular chaperone/chaperonin-binding protein; Pacrg; PARK2 coregulated; PARK2 co-regulated; PARK2 coregulated gene protein; PARK2CRG; Parkin coregulated gene protein; parkin co-regulated gene protein; parkin coregulated gene protein homolog; RGD1561027; RP3-495O10.2