p27 Proteins

Protein Information

p27, also known as p27Kip1, is a crucial cyclin-dependent kinase inhibitor (CKI) involved in the regulation of the cell cycle. The p27 protein is encoded by the CDKN1B gene located on chromosome 12 and plays a vital role in controlling cell proliferation by inhibiting cyclin-CDK complexes, particularly cyclin A-CDK2 and cyclin E-CDK2. By regulating these complexes, p27 induces cell cycle arrest at the G1 phase, preventing cells from prematurely entering the S phase. This function is critical for maintaining normal cellular processes and preventing uncontrolled cell division. p27 acts as a tumor suppressor, and its expression is tightly controlled by transcriptional and post-transcriptional mechanisms, including proteasome-mediated degradation. Reduced levels of p27 have been associated with numerous cancers, highlighting its role in tumorigenesis. The regulation of p27 involves signaling pathways such as the PI3K/AKT pathway, impacting its localization and stability in response to extracellular signals.

Synonyms

CGI-109; p24 family protein gamma-3; p24g3; p24gamma3; p27; TMED7; transmembrane emp24 domain-containing protein 7; transmembrane emp24 protein transport domain containing 7; transmembrane p24 trafficking protein 7