MARCKSL1 Proteins

Protein Information

MARCKS (Myristoylated alanine-rich protein kinase C substrate), also designated 80K or 80K-L, is a 332 amino acid protein that localizes to the plasma membrane and functions as a major cellular substrate for protein kinase C (PKC). MARCKSL1 (MARCKS-like protein 1), also known as MacMARCKS, MLP, MRP, or F52, is a 195 amino acid protein that, like MARCKS, is a major substrate for PKC. Expressed in a variety of tissues with highest levels found in testis and uterus, MARCKSL1 participates in the coordination of membrane-cytoskeletal signaling events, including secretion, migration, phagocytosis and cell adhesion. Additionally, MARCKSL1 functions as a regulator of Integrin activation and is thought to regulate Integrin-dependent signal transduction pathways, especially those involved in macrophage spreading.

Synonyms

AL022768; AW215397; AW536807; Brain protein F52; D4Bc1; F52; macMARCKS; Mac-MARCKS; Macrophage myristoylated alanine-rich C kinase substrate; Macs2; Macs3; MARCKS like 1; MARCKSL1; MARCKS-like 1; MARCKS-like protein 1; MARCKS-related protein; MLP; MLP1; MRP; myristoylated alanine-rich C kinase substrate