JAKMIP1 Proteins

Protein Information

JAKMIP1, also known as Marlin-1, is a highly-conserved vertebrate-specific microtubule-associated protein that plays a role in JAK1 signaling and regulate microtubule cytoskeleton rearrangements. JAKMIP1 is expressed predominantly in neuronal and lymphoid cells and colocalizes with microtubules. Multiple isoforms of JAKMIP1 are known to exist: isoforms 1 and 5 are also expressed in liver, lung and skeletal muscle, while isoforms 2-4 are specifically expressed in brain and retina. JAKMIP1 participates in polarized secretion in lymphocytes and it has been suggested to be a novel effector memory gene restraining T cell-mediated cytotoxicity. Dysregulation of JAKMIP1 gene expression is associated with genetic conditions linked to autism in humans.

Synonyms

5830437M04Rik; C330021K24Rik; FLJ31564; GABA-B receptor-binding protein; Gababrbp; gamma-aminobutyric acid (GABA-B) receptor binding protein; Jak and microtubule interacting protein 1; Jakmip1; JAMIP1; janus kinase and microtubule interacting protein 1; janus kinase and microtubule-interacting protein 1; MARLIN1; Marlin-1; Multiple alpha helices and RNA-linker protein 1; multiple alpha-helices and RNA-linker protein 1; multiple coiled-coil GABABR1-binding protein