EGFL6 Proteins

Protein Information

The EGFL6 gene encodes epidermal growth factor-like domain-containing protein 6, a member of the EGF-like repeat superfamily known for its roles in development and angiogenesis. EGFL6 is expressed at higher levels during embryonic development and has notable expression in various malignant tumors, highlighting its potential involvement in cancer progression. This secreted protein is pivotal in promoting tumor angiogenesis, influencing cancer cell migration and proliferation without affecting wound healing, making it a significant factor in tumor growth and metastasis. EGFL6 is also expressed in adipose tissues, and its role in adipose differentiation suggests it might link obesity to endometrial cancer risks. The protein impacts cellular activities such as cell adhesion, migration, and proliferation, contributing fundamentally to tumor dynamics. Consequently, EGFL6 is considered an attractive target for antibody-based therapies, with research evaluating its utility in cancer intervention strategies.

Synonyms

EGF like domain multiple 6; EGF repeat-containing protein 6; Egfl6; EGF-like protein 6; EGF-like-domain, multiple 6; Epidermal growth factor-like protein 6; Maeg; MAM and EGF domain containing; MAM and EGF domains-containing gene protein; PP648; Protein W80; UNQ281/PRO320; W80