DPH5 Proteins

Protein Information

This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Synonyms

AD-018; CGI-30; diphthamide biosynthesis 5; diphthamide biosynthesis methyltransferase; Diphthine methyl ester synthase; diphthine synthase; DPH5; DPH5 homolog; HSPC143; NPD015; protein x 0011