CTDSPL Proteins

Protein Information

Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. [UniProt]

Synonyms

2810418J22Rik; AI426263; C3orf8; Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3; CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like; CTD small phosphatase like; CTD small phosphatase-like protein; Ctdspl; CTDSP-like; hYA22; MGC71888; Nif1; Nifl; NIF-like protein; NLI-interacting factor 1; nuclear LIM interactor-interacting factor 1; Protein YA22; PSR1; RB protein serine phosphatase from chromosome 3; RBSP3; SCP3; SCP-3; SCP3 COR1; small CTD phosphatase 3; Small C-terminal domain phosphatase 3; YA22