CNOT6 Proteins

Protein Information

Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein-coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. In the presence of ZNF335, enhances ligand-dependent transcriptional activity of nuclear hormone receptors, including RARA. The increase of ligand-dependent ESR1-mediated transcription is much smaller, if any. Mediates cell proliferation and cell survival and prevents cellular senescence.

Synonyms

carbon catabolite repression 4 protein; carbon catabolite repressor protein 4 homolog; Ccr4; CCR4 carbon catabolite repression 4-like; Ccr4a; CCR4-NOT transcription complex subunit 6; CCR4-NOT transcription complex, subunit 6; Cnot6; cytoplasmic deadenylase; Kiaa1194; RGD1310783