CLSTN1 Proteins

Protein Information

CLSTN1 induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, CLSTN1 stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, CLSTN1 abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding.CLSTN1 may modulate calcium-mediated postsynaptic signals.

Synonyms

1810034E21Rik; alcadein alpha; Alcadein-alpha; ALC-ALPHA; alcalpha1; alcalpha2; Alzheimer-related cadherin-like protein; cadherin-related family member 12; calsyntenin 1; Calsyntenin-1; CDHR12; Clstn1; CS1; Cst-1; Cstn1; C-terminal fragment 1-alpha; CTF1-alpha; FLJ32258; KIAA0911; Non-classical cadherin XB31alpha; PIK3CD; SAlc-alpha; Soluble Alc-alpha; XB31alpha