CHI3L1 Proteins

Protein Information

Human cartilage glycoprotein 39 (GP-39), also known as YKL-40, is a glycoprotein secreted by articular chondrocytes, synoviocytes and macrophages. Serum and synovial fluid GP-39 levels are elevated in inflammatory diseases and correlate with the degree of joint destruction in rheumatoid arthritis. GP-39 is expressed in articular chondrocytes and synovial cells, as well as in liver, but is undetectable in muscle tissues, lung, pancreas, mononuclear cells and fibroblasts. GP-39 is a candidate autoantigen in rheumatoid arthritis and is important in the capacity of cells to respond to and cope with changes in their environment.

Synonyms

39 kDa synovial protein; ASRT7; AW208766; Breast regression protein 39; Brp39; BRP39 protein; Cartilage glycoprotein 39; CGP39; CGP-39; Chi3l1; Chil1; chitinase 3 like 1; Chitinase 3 like protein 1CGP 39; chitinase 3-like 1; chitinase 3-like 1 (cartilage glycoprotein-39); chitinase 3-like 1 protein; chitinase-3-like protein 1; chitinase-like 1; DKFZp686N19119; FLJ38139; Gp39; GP-39; hCGP39; HC-gp39; hCGP-39; HCGP-3P; YKL40; YKL-40; YYL-40