CD82 Proteins

Protein Information

This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Synonyms

4F9; AA682076; AL023070; C33; C33 antigen; CD82; CD82 antigen; CD82 antigen (R2 leukocyte antigen antigen detected by monoclonal and antibody IA4)); CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4)); CD82 molecule; GR15; IA4; Inducible membrane protein R2; Kai1; Kangai 1 (suppression of tumerigenicity 6 prostate) CD82 antigen; kangai 1 (suppression of tumorigenicity 6), prostate; kangai 1 (suppression of tumorigenicity 6, prostate); Kangai 1 (suppression of tumorigenicity 6, prostate; CD82 antigen (R2 leukocyte antigen, antigen detected by monoclonal and antibody IA4)); metastasis suppressor Kangai-1; Metastasis suppressor Kangai-1 homolog; R2; SAR2; ST6; Suppressor of tumorigenicity 6 protein; Tetraspanin-27; TSPAN27; Tspan-27