CCDC171 Proteins

Protein Information

Chromosome 9 consists of about 145 million bases and 4% of the human genome and encodes nearly 900 genes. Considered to play a role in gender determination, deletion of the distal portion of 9p can lead to development of male to female sex reversal, the phenotype of a female with a male X,Y genotype. Hereditary hemorrhagic telangiectasia, which is characterized by harmful vascular defects, is associated with the chromosome 9 gene encoding endoglin protein, ENG. Familial dysautonomia is also associated with chromosome 9 though through the gene IKBKAP. Notably, chromosome 9 encompasses the largest interferon family gene cluster. Chromosome 9 is partnered with chromosome 22 in the translocation leading to the aberrant production of BCR-ABL fusion protein often found in leukemias. There are two isoforms of C9orf93 that are produced as a result of alternative splicing events.

Synonyms

bA536D16.1; bA778P13.1; C9orf93; CCDC171; coiled-coil domain containing 171; coiled-coil domain-containing protein 171; myosin tail domain containing protein