CCDC123 Proteins

Protein Information

CCDC123 (as known as CEP123), also named as CEP89, is a new player in the process of primary ciliogenesis and it also plays a role in mitochondrial metabolism where it may modulate complex IV activity. It has been shown that CEP123 is localized to the distal appendages of the mother centriole and the localization of CEP123 is cell cycle-dependent with its levels decreasing during mitosis. CEP123 depletion can cause defects in ciliary vesicle formation and prevent the formation of a ciliary vesicle at the distal end of the mother centriole. It is possible that CEP123 is involved in regulating the recruitment of membranes to the centrosome.

Synonyms

CCDC123; Centrosomal protein 123; centrosomal protein 89; centrosomal protein 89kDa; centrosomal protein of 89 kDa; Cep123; Cep89; coiled-coil domain containing 123; Coiled-coil domain-containing protein 123; coiled-coil domain-containing protein 123, mitochondrial