CAND1 Proteins

Protein Information

CAND1 enhances transcription from various types of promoters. It is a regulatory protein that interferes with the assembly of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex and thereby down-regulates ubiquitination of target proteins. CAND1 prevents neddylation of CUL1 by physically blocking access to the neddylation site. CAND1 disrupts interactions between CUL1 and SKP1A and between CUL1 and F-box proteins.

Synonyms

2310038O07Rik; 6330512O03Rik; AI195005; AI846556; Cand1; cullin associated and neddylation disassociated 1; cullin associated and neddylation dissociated 1; cullin-associated and neddylation-dissociated 1; cullin-associated and neddylation-dissociated protein 1; Cullin-associated NEDD8-dissociated protein 1; D10Ertd516e; DKFZp434M1414; FLJ10114; FLJ10929; FLJ38691; FLJ90441; KIAA0829; mKIAA0829; p120 CAND1; TBP interacting protein; TBP-interacting protein; TBP-interacting protein 120A; TBP-interacting protein of 120 kDa A; TBP-interacting protein TIP120A; TIP120; Tip120A; Tp120a