C9orf7 Proteins

Protein Information

Transmembrane protein which mediates synaptic endocytosis and fitness-based cell culling. In response to different stimulus strengths, controls two major modes of synaptic vesicle (SV) retrieval in hippocampal neurons; Clathrin- mediated endocytosis (CME) in response to mild stimulation and activity-dependent bulk endocytosis (ADBE) in response to strong stimulation (By similarity). In cytotoxic T-lymphoocytes (CTLs) facilitates calcium-dependent endocytosis of cytotoxic granules at the immuno synapse (By similarity). Different isoforms work as fitness fingerprints in 'loser' and 'winner' cells and thereby mediate win/lose decisions as part of the cell competition process.

Synonyms

5930434B04Rik; C9orf7; CACFD1; calcium channel flower domain containing 1; calcium channel flower domain-containing protein 1; Calcium channel flower homolog; D9S2135; FLOWER; likely ortholog of H. sapiens chromosome 9 open reading frame 7 (C9orf7); mFwe; PSEC0107; PSEC0248; RGD1311501; UNQ3071/PRO9903