BLNK Proteins

Protein Information

B cell linker protein (Blnk) is a protein encoded by the Blnk gene located on chromosome 10 in humans. It is also known as SLP 65 (Src homology 2 domain-containing leukocyte protein of 65 kDa). It derives its name from being an adaptor protein in the B cell receptor signaling cascade with several supporting studies showing improper development of B cells in the absence of Blnk. Blnk undergoes tyrosine phosphorylation by Syk, a B cell receptor activated kinase, which provides a platform for interaction of signaling intermediaries such as the Vav GEF and Grb2.

Synonyms

AGM4; B cell adaptor containing SH2 domain; B cell linker; B cell linker protein; Bash; bca; B-cell activation; B-cell adapter containing a SH2 domain protein; B-cell adapter containing a Src homology 2 domain protein; B-cell linker; B-cell linker protein; Blnk; BLNK-S; cytoplasmic adapter protein; Ly57; Ly-57; Lymphocyte antigen 57; Lyw-57; MGC111051; SLP65; SLP-65; Src homology [SH2] domain-containing leukocyte protein of 65 kD; src homology 2 domain-containing leukocyte protein of 65 kDa