BICD1 Proteins

Protein Information

BICD1 was initially identified as the human homolog to Drosophila Bicaudal-D protein that forms part of the cytoskeleton and mediates the correct sorting of mRNAs for oocyte- and axis-determining factors during oogenesis. BICD1 can bind to dynein-dynactin and co-localizes with Rab6A on the trans-Golgi network and cytoplasmic vesicles, suggesting BICD1 regulates COPI-independent Golgi-ER transport. BICD1 will also interact with Rab6B, a Rab6 isoform that is expressed primarily in brain. Live cell imaging showed bi-directional movement of Rab6B structures in SK-N-SH neurites, indicating that BICD1 is involved in the Rab6B regulation of retrograde cargo transport in neuronal cells.

Synonyms

B830009D06Rik; bicaudal D homolog 1; bicaudal D homolog 1 (Drosophila); BICD; Bic-D 1; BICD cargo adaptor 1; Bicd1; cytoskeleton-like bicaudal D protein homolog 1; protein bicaudal D homolog 1