BCL2A1 Proteins

Protein Information

Bcl-2 related Protein A1 is a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.

Synonyms

A1; A1-A; ACC1; ACC-1; ACC2; ACC-2; B cell leukemia/lymphoma 2 related protein A1a; BB218357; B-cell leukemia/lymphoma 2 related protein A1; B-cell leukemia/lymphoma 2 related protein A1a; B-cell leukemia/lymphoma 2 related protein A1d; BCL2 related protein A1; Bcl2a1; Bcl2a1a; Bcl2a1d; BCL2L5; bcl2-L-5; Bcl-2-like protein 5; bcl-2-related protein A1; BCL2-related protein A1; BCL2-related protein A1d; Bfl1; Bfl-1; GRS; GRS protein; HBPA1; hematopoietic BCL2-related protein A1; hemopoietic-specific early response protein; Protein BFL-1; Protein GRS