ATP6V1B2 Proteins

Protein Information

ATP6V1B2 encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain B subunit isoforms and is the only B isoform highly expressed in osteoclasts.

Synonyms

AI194269; AI790362; ATP6B1B2; ATP6B2; Atp6v1b2; ATPase H+ transporting V1 subunit B2; ATPase, H transporting, lysosomal V1 subunit B2; ATPase, H+ transporting, lysosomal (vacuolar proton pump), beta 56/58 kDa, isoform 2; ATPase, H+ transporting, lysosomal 56/58kD, V1 subunit B, isoform 2; ATPase, H+ transporting, lysosomal 56/58kDa, V1 subunit B2; ATPase, H+ transporting, lysosomal V1 subunit B2; ATPase, H+ transporting, V1 subunit B, isoform 2; DOOD; Endomembrane proton pump 58 kDa subunit; H+ transporting two-sector ATPase; HO57; lysosomal 56/58kDa; R74844; testicular secretory protein Li 65; vacuolar H+-ATPase 56,000 subunit; vacuolar H+ATPase B2; vacuolar proton pump subunit B 2; Vat2; Vatb; V-ATPase B2 subunit; V-ATPase subunit B 2; Vma2; VPP3; V-type proton ATPase subunit B, brain isoform; ZLS2