ATG10 Proteins

Protein Information

ATG10 is involved in autophagy which is a process for the bulk degradation of cytosolic compartments by lysosomes/vacuoles. The formation of autophagosomes involves a dynamic rearrangement of the membrane for which two ubiquitin-like modifications (the conjugation of APG12p and the modification of a soluble form of MAP-LC3 to a membrane-bound form) are essential. APG10 is an E2-like enzyme involved in two ubiquitin-like modifications essential for autophagosome formation, ATG12 -ATG5 conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A), a homolog of yeast Apg8, to a membrane-bound form. The protein ATG10 is ubiquitously expressed and the human APG10L gene is localized on chromosome 5q14.2.

Synonyms

5330424L23Rik; 5430428K15Rik; Agp10; AI852123; APG10; Apg10l; APG10-like; Apg10p; ATG10; ATG10 autophagy related 10 homolog; Atg10l; autophagy related 10; autophagy related 10 homolog; autophagy-related 10; autophagy-related protein 10; DKFZp586I0418; FLJ13954; mAPG10; pp12616; Ubiquitin-like-conjugating enzyme ATG10