ASCC1 Proteins

Protein Information

This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.

Synonyms

1810015P09Rik; Activating signal cointegrator 1 complex subunit 1; AI550520; Asc-1; ASC-1 complex subunit p50; ASC1p50; Ascc1; CGI-18; p50; SMABF2; trip4 complex subunit p50