ARID5B Proteins

Protein Information

ARID5B encodes a member of the AT-rich interaction domain (ARID) family of DNA binding proteins. The encoded protein forms a histone H3K9Me2 demethylase complex with PHD finger protein 2 and regulates the transcription of target genes involved in adipogenesis and liver development. ARID5B also plays a role in cell growth and differentiation of B-lymphocyte progenitors, and single nucleotide polymorphisms in this gene are associated with acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Synonyms

ARID domain-containing protein 5B; ARID5B; AT rich interactive domain 5B (MRF1-like); AT-rich interaction domain 5B; AT-rich interactive domain 5B (MRF1-like); AT-rich interactive domain-containing protein 5B; DESRT; Modulator recognition factor 2; modulator recognition factor 2 (MRF2); MRF1-like protein; MRF2; MRF-2