ARHGDIG Proteins

Protein Information

The Ras superfamily of small GTP-binding proteins are critical mediators of diverse cell signaling pathways, including those leading to proliferation, cytoskeletal organization and secretion. The counter-conversion of the active GTPbound form of these proteins to their inactive GDP-bound form is influenced by two types of regulatory proteins: those that alter the intrinsic GTPase activity of the GTP-binding proteins and those that alter the rate of GDP/GTP exchange. Guanine nucleotide-releasing factors (GRFs) increase the GDP dissociation rate, while GDP-dissociation inhibitors (GDIs) decrease the dissociation rate. The Rho GDI subfamily is composed of Rho GDIalpha, Ly-GDI (also known as Rho GDIbeta and previously known as GDI/D4) and Rho GDIgamma. The Rho GDI proteins interact with and have varying affinities for several Ras-like GTP binding proteins, including Rho A, Rho B, Rac and Cdc42. Ly-GDI is expressed only in hematopoietic cells, predominantly in B and T lymphocyte cell lines.

Synonyms

Arhgdig; Gdi5; guanosine diphosphate (GDP) dissociation inhibitor 5, Rho associated; rho GDI 3; Rho GDIgamma; Rho GDP dissociation inhibitor (GDI) gamma; Rho GDP dissociation inhibitor gamma; rho GDP-dissociation inhibitor 3; RhoGDI gamma; Rho-GDI gamma; Rho-GDI2; Rho-GDI-3; RHOGDI-3; Rho-GDIgamma; RIP2