ARFGAP3 Proteins

Protein Information

The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene.

Synonyms

0610009H19Rik; 1810004P07Rik; 1810035F16Rik; 9130416J18Rik; ADP ribosylation factor GTPase activating protein 3; ADP-ribosylation factor GTPase activating protein 1; ADP-ribosylation factor GTPase activating protein 3; ADP-ribosylation factor GTPase-activating protein 3; ARF GAP 3; ARF1GAP; Arfgap1; ARFGAP3; arfgap3 {ECO:0000250; FLJ45618; HRIHFB2281; MGC39924; OTTHUMP00000028526; RP11-261N11.1; RP1-47A17.3; UniProtKB:Q9NP61}