ARAP3 Proteins

Protein Information

Ubiquitin is a conserved 76 amino acid polypeptide and can affect proteasomal degradation of the protein it is bound to, or mediate interactions with other proteins related to post-translational modifications. The degradation of cellular regulatory proteins by the Uubiquitin pathway is important as it controls the cellular growth and proliferation. Ubiquitin-dependent proteolysis occurs after a covalent attachment of the peptide to a lysine residue of a protein, which involves three enzymatic reactions: E1, E2 and E3. The first reaction involves ubiquitin-activating enzyme. The third reaction uses enzyme ubiquitin ligase (E3) to transfer the activated ubiquitin from E2 to a lysine residue on a protein, or directly transfers the ubiquitin from E2 to the substrate.

Synonyms

ARAP3; Arf and Rho GAP adapter protein 3; arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3; ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3; ARF-GAP, RHO-GAP, ankyrin repeat and plekstrin homology domains-containing protein 3; centaurin; centaurin, delta 3; centaurin-delta-3; CENTD3; Cnt-d3; DRAG1; FLJ21065; phosphoinositide binding protein; PtdIns(3,4,5)P3-binding protein