APLP1 Proteins

Protein Information

This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.

Synonyms

amyloid beta (A4) precursor-like protein 1; amyloid beta precursor like protein 1; amyloid precursor-like protein 1; Amyloid-like protein 1; APLP; APLP 1; Aplp1; APLP-1; Aplp1_retired; APLPAPLP-1; C30; RGD1561211