ANO3 Proteins

Protein Information

The protein encoded by this gene belongs to the TMEM16 family of predicted membrane proteins, that are also known as anoctamins. While little is known about the function of this gene, mutations in this gene have been associated with some cases of autosomal dominant craniocervical dystonia. Cells from individuals with a mutation in this gene exhibited abnormalities in endoplasmic reticulum-dependent calcium signaling. Studies in rat show that the rat ortholog of this protein interacts with, and modulates the activity of a sodium-activated potassium channel. Deletion of this gene caused increased pain sensitivity in the rat model system. Alternative splicing results in multiple transcript variants encoding different isoforms.

Synonyms

AI838058; Ano3; anoctamin 3; anoctamin-3; B230324K02Rik; C11orf25; DYT23; DYT24; GENX-3947; TMEM16C; Transmembrane protein 16C; transmembrane protein 16C (eight membrane-spanning domains)