AGFG1 Proteins

Protein Information

HRB is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. HRB binds the activation domain of the human immunodeficiency virus Rev protein when Rev is assembled onto its RNA target, and is required for the nuclear export of Rev-directed RNAs. The protein encoded by this gene is related to nucleoporins, a class of proteins that mediate nucleocytoplasmic transport. This encoded protein binds the Rev activation domain when Rev is assembled onto its RNA target and can significantly enhance Rev activity when overexpressed. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.

Synonyms

AGFG1; Agfg1-ps1; Arf-GAP domain and FG repeat-containing protein 1; arf-GAP domain and FG repeats-containing protein 1; ArfGAP with FG repeats 1; AU045498; C130049H11Rik; C85612; D730048C23Rik; HIV-1 Rev binding protein; HIV-1 Rev-binding protein; HIV-1 Rev-binding protein homolog; Hrb; hRIP, Rev interacting protein; MGC116938; MGC116940; nucleoporin-like protein RIP; RAB; Rab, Rev/Rex activation domain-binding protein; Rev/Rex activation domain-binding protein; rev-interacting protein; RIP