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Gibco
PeproGMP® Human SCF Recombinant Protein, PeproTech®
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PeproGMP® Human SCF Protein (GMP300-07-50UG) in Functional
Product Details
GMP300-07-50UG
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Product Specific Information
Stem cell factor (SCF) is a hematopoietic growth factor that exerts its activity by signaling through the c-Kit receptor. SCF and c-Kit are essential for the survival, proliferation and differentiation of hematopoietic stem cells (HSCs) and progenitors committed to the melanocyte and germ cell lineages, ensuring proper blood and immune cell development. The human SCF gene encodes for a 273 amino acid transmembrane protein, which contains a 25 amino acid N-terminal signal sequence, a 189 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 36 amino acid cytoplasmic domain. The secreted soluble form of SCF is generated by proteolytic processing of the membrane anchored precursor. PeproTech Recombinant Human SCF is an 18.4 kDa polypeptide containing 165 amino acid residues, which corresponds to the sequence of the secreted soluble form of SCF.
PeproGMP SCF cytokine is most often used with PeproGMP TPO (thrombopoietin) and PeproGMP Flt3-ligand in HSC cultures, along with IL-3 and IL-6 for further synergistic expansion and immune cell maturation.
Additional product information , specifications, handling and reconstitution information are provided on the Certificate of Analysis.
All PeproGMP® products are manufactured using animal-derived component free materials.
Product Description/Intended Use: PeproTech GMP recombinant proteins are manufactured for use as ancillary materials by applying applicable principles of GMP and quality control requirements from USP (United States Pharmacopeia) Chapter <1043> Ancillary Materials for Cell, Gene, and Tissue-Engineered Products.
Target Information
Stem cell factor (SCF) is the ligand of the c-Kit oncogene and is expressed by various structural and inflammatory cells in the airways. Binding of SCF by the c-Kit receptor leads to homodimerization of the receptor and the activation of signalling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase pathways. SCF expression leads to the induction of mast cell survival and the expression and release of histamine, pro-inflammatory cytokines and chemokines. The inhibition of the SCF/c-Kit pathway leads to a decrease in histamine levels, mast cell and eosinophil infiltration, IL-4 production and airway hyperresponsiveness, suggesting this pathway may be a useful therapeutic target in inflammatory diseases such as asthma. At least two isoforms of SCF are known to exist.
For research use or further manufacturing. Not for diagnostic use or direct administration into humans or animals.
References (0)
Bioinformatics
Protein Aliases: c-Kit ligand; DKFZp686F2250; familial progressive hyperpigmentation 2; H-SCF; Kit ligand; kit-ligand; M-SCF; Mast cell growth factor; MGF; SCF; steel factor; Stem cell factor
Gene Aliases: DCUA; DFNA69; FPH2; FPHH; Kitl; KITLG; KL-1; MGF; SCF; SF; SHEP7
UniProt ID: (Human) P21583
Entrez Gene ID: (Human) 4254
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